EPA魚油怎麼吃才有效?營養師教你魚油正確劑量與挑選關鍵

 

講到高血脂和心血管的保健品,很多人都會想到魚油,這是因為魚油中的營養成分:EPA(二十碳五烯酸, Eicosapentaenoic Acid)。EPA扮演著抗發炎與調節血脂的角色,對於現代人常見的三高、代謝症候群,甚至情緒問題都很有幫助。那麼EPA要吃多少才有效果?要如何挑選EPA魚油或磷蝦油?林安安營養師整理出2025年最新版EPA建議劑量和挑選重點,提供最實用的保健指南。


1. EPA是什麼?心血管保健的機制與原理

三酸甘油酯過高是心血管疾病的重要危險因子,而 EPA正是臨床實證中最有效降低三酸甘油酯的營養素之一。其作用機制包含:

  1. 降低多項發炎指標,例如CRP、TNF-α、IL-6 等 (6)。生成抗發炎物質resolvins,整體降低慢性發炎反應(7)
  2. 抗血液凝集,有研究指出EPA具有抑制血小板凝集的作用,能抗血栓(5)
  3. 抑制肝臟合成,EPA能直接抑制肝臟內生成三酸甘油酯的酵素,減少產生(15)

 


2. EPA要吃多少才有效果?國際建議劑量

2.1. 美國心臟協會(AHA)

一般健康者,建議每日250-500毫克EPA+DHA:

血脂偏高者,每日攝取2–4公克EPA+DHA,可讓三酸甘油酯下降20–30%

 

2.2. EPA大型臨床研究

高三酸甘油酯患者每日補充4公克純EPA,能降低心血管疾病發生風險(4)

 

2.3. 美國婦產科期刊:母嬰醫學(American Journal of Obstetrics and Gynecology)

孕婦與哺乳婦女建議每天 350–450 mg EPA+DHA,其中需特別注意DHA的補充,但EPA也能幫助調節孕期發炎反應與血壓(3)

 

● 延伸閱讀>> EPA一天要吃多少?最完整EPA魚油10大功效與正確建議魚油劑量


3. 如何挑選高品質EPA魚油/磷蝦油?

  • 純淨來源:挑選小型魚(鯷魚、沙丁魚)或南極海域的磷蝦,污染低
  • 吸收型態:再酯化甘油三酯型(rTG魚油)或磷脂型(磷蝦油),兩者生物利用率高,以磷蝦油為最佳 
  • 實際含量:產品換算每日攝取的EPA + DHA總量,避免攝取不足
  • 檢驗認證:是否有相關定期檢驗與認證,以確保品質與安全

 


4. EPA魚油/磷蝦油總結

EPA 是守護心血管、幫助抗發炎的重要營養素,不論是年輕人還是長輩,都少不了它對身體健康的支持。

林安安營養師建議大家平時可以透過飲食補充,每天至少兩份魚類,就能大致補足EPA與DHA的需求。但如果覺得天天吃魚不太容易做到,或是想要追求 更好吸收、更高效又多元的補充方式,那麼魚油及磷蝦油的補充品就是一個很不錯的進階選擇!

 

加入追蹤林安安營養師粉絲團,用營養蘊育健康!

 


參考文獻

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  2. Skulas‑Ray, A. C., Wilson, P. W. F., Harris, W. S., Brinton, E. A., Kris‑Etherton, P. M., & American Heart Association. (2019). Omega‑3 fatty acids for the management of hypertriglyceridemia: A science advisory from the American Heart Association. Circulation, 140(12), e673–e691. [Link]
  3. Middleton P, et al. (2018). Omega-3 fatty acid addition during pregnancy. Cochrane Database of Systematic Reviews. [Pubmed]
  4. Bhatt, D. L., et al. (2019). Cardiovascular risk reduction with icosapent ethyl for hypertriglyceridemia. New England Journal of Medicine, 380(1), 11–22. [Link]
  5. Mozaffarian, D., & Wu, J. H. (2011). Omega-3 fatty acids and cardiovascular disease. Journal of the American College of Cardiology, 58(20), 2047–2067. [Link]
  6. Schiano V., Laurenzano E., Brevetti G. et al: Omega-3 polyunsaturated fatty acid in peripheral arterial disease: effect on lipid pattern, disease severity, inflammation profile, and endothelial function. Clin Nutr 2008; 27: 241. [Pubmed]
  7. Calder, P. C. (2017). Omega-3 fatty acids and inflammatory processes: From molecules to man. Biochemical Society Transactions, 45(5), 1105–1115. [Link]
  8. Geleijnse J.M., Giltay E.J., Grobbee D.E., Donders A.R. and Kok F.J.: Blood pressure response to fish oil supplementation: metaregression analysis of randomized trials. J Hypertens 2002; 20: 1493. [Pubmed]
  9. Kenny D., Warltier D.C., Pleuss J.A., Hoffmann R.G., Goodfriend T.L. and Egan B.M.: Effect of omega-3 fatty acids on the vascular response to angiotensin in normotensive men. Am J Cardiol 1992; 70: 1347. [PubMed]
  10. Jerome Sarris et al., Adjunctive Nutraceuticals for Depression: A Systematic Review and Meta-Analyses. American Journal of Psychiatry Volume 173, Number 6. [Link]
  11. The Relationship of Omega-3 Fatty Acids with Dementia and Cognitive Decline: Evidence from Prospective Cohort Studies of Supplementation, Dietary Intake, and Blood Markers. Bao-Zhen Wei et al., The American Journal of Clinical Nutrition, 117(6), 1096-1109 [Pubmed
  12. Artemis P. Simopoulos et al., Dietary Omega-3 Fatty Acid Deficiency and High Fructose Intake in the Development of Metabolic Syndrome, Brain Metabolic Abnormalities, and Non-Alcoholic Fatty Liver Disease. Nutrients 2013, 5(8), 2901-2923. [Link]
  13. Saccà, S., Cutolo, C., Ferrari, D., Corazza, P. & Traverso, C. The Eye, Oxidative Damage and Polyunsaturated Fatty Acids. Nutrients 10, 668 (2018). [Pubmed]
  14. Single-dose bioavailability of the Multiple Formulations of NKO®.NEPT1000 Clinical Study Report.
  15. Bornfeldt, K. E. (2021). Triglyceride lowering by omega-3 fatty acids: a mechanism mediated by N-acyl taurines, 32(2), 63–69. [Pubmed]


 

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